Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study.

ABSTRACT:

Background

Ca(2+) channel blockers (CCB) and verapamil in particular prevented β-cell apoptosis and enhanced endogenous insulin levels in recent studies of mouse models of diabetes. Verapamil's effect on serum glucose levels in humans with diabetes is not described.

Methods

We used data from the REasons for Geographic and Racial Differences in Stroke (REGARDS), a national cohort study of community-dwelling middle-aged and older adults, enrolled between 2003 and 2007 from the continental United States. We examined associations of CCB and verapamil use with fasting serum glucose among 4978 adults with diabetes, controlling for covariates in generalized linear models (GLM).

Findings

The sample included 1484 (29.6%) CCB users, of which 174 (3.4%) were verapamil users. In

SUBMITTER: Khodneva Y 

PROVIDER: S-EPMC4887408 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature