Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study.

ABSTRACT:

Background

Anastomotic leakage (AL) after colorectal surgery is a severe complication, resulting in morbidity, reinterventions, prolonged hospital stay and, in some cases, death. Some technical and patient-related aetiological factors of AL are well established. In many cases, however, none of these factors seem to explain the occurrence of AL. Recent studies suggest that the intestinal microbiome plays a role in wound healing, diabetes and Crohn's disease. The aim of this study was to compare the intestinal microbiota of patients who developed AL with matched patients with healed colorectal anastomoses.

Methods

We investigated the microbiome in the doughnuts collected from 16 patients participating in the C-seal trial. We selected eight patients who developed AL requiring r

SUBMITTER: van Praagh JB 

PROVIDER: S-EPMC4887536 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature