Cardiovascular safety of methylphenidate among children and young people with attention-deficit/hyperactivity disorder (ADHD): nationwide self controlled case series study.

ABSTRACT:

Objective

 To determine whether treatment with methylphenidate in children and young people with attention-deficit/hyperactivity disorder (ADHD) was associated with cardiovascular events.

Design

 Self controlled case series analysis.

Setting

 Nationwide health insurance database, 1 January 2008 to 31 December 2011, in South Korea.

Participants

 1224 patients aged ≤17 who had experienced an incident cardiovascular event and had had at least one incident prescription for methylphenidate.

Main outcome measures

 A recorded diagnosis (either a primary or secondary cause) of any of the following cardiovascular adverse events: arrhythmias (ICD-10 (international classification of diseases, 10th revision) codes I44, I45, I47, I48, I49), hypertension (codes I10-I1

SUBMITTER: Shin JY 

PROVIDER: S-EPMC4887614 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature