Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria.

ABSTRACT: Plasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, exported and presented at the infected erythrocyte membrane. To identify new CM-specific parasite membrane proteins, we conducted a mass spectrometry-based proteomic study and compared the protein expression profiles between 9 CM and 10 uncomplicated malaria (UM) samples. Among the 1097 Plasmodium proteins identified, we focused on the 499 membrane-associated and hypothetical proteins for comparative analysis. Filter-based feature selection methods combined with supervised data analysis identified a subset of 29 proteins distinguishing CM and UM samples with high classification accuracy. A hierarchical clustering analysi

SUBMITTER: Bertin GI 

PROVIDER: S-EPMC4887788 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature