Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation.

ABSTRACT:

Background

A variety of environmental factors have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation in numerous species. Exposure to environmental factors such as toxicants can promote epigenetic changes (epimutations) involving alterations in DNA methylation to produce specific differential DNA methylation regions (DMRs). The germline (e.g. sperm) transmission of epimutations is associated with epigenetic transgenerational inheritance phenomena. The current study was designed to determine the genomic locations of environmentally induced transgenerational DMRs and assess their potential clustering.

Results

The exposure specific DMRs (epimutations) from a number of different studies were used. The clustering approach ident

SUBMITTER: Haque MM 

PROVIDER: S-EPMC4888261 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature