Brain MRI Volume Findings in Diabetic Adults With Albuminuria: The ACCORD-MIND Study.

ABSTRACT:

Background

Albuminuria is associated with cognitive impairment in people with type 2 diabetes mellitus (T2DM). The brain volume correlates of albuminuria in people with T2DM have not been well investigated.

Methods

We examined 502 individuals with T2DM (9-12 years duration; mean age ~62 years) who had a brain MRI at baseline and at 40 months. Baseline MRI findings were examined by the presence or absence of albuminuria (≥30mg/g creatinine). Changes in MRI findings were examined by whether albuminuria was persistent, intermittent, or absent during follow-up.

Results

At baseline, participants with albuminuria (28.7% of the cohort) had more abnormal white matter volume (AWMV) than participants without albuminuria on unadjusted analysis. This difference was attenuated wit

SUBMITTER: Barzilay JI 

PROVIDER: S-EPMC4888390 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature