Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities.

ABSTRACT: Matrix metalloproteases (MMPs) are crucial components of a complex and dynamic network of proteases. With a wide range of potential substrates, their production and activity are tightly controlled by a combination of signalling events, zymogen activation, post-translational modifications and extracellular inhibition. Slight imbalances may result in the initiation or progression of specific disease states, such as cancer and pathological inflammation. As glycosylation modifies the structures and functions of glycoproteins and many MMPs contain N- or O-linked oligosaccharides, we examine, compare and evaluate the evidence for whether glycosylation affects MMP catalytic activity and other functions. It is interesting that the catalytic sites of MMPs do not contain O-linked glycans, but instea

SUBMITTER: Boon L 

PROVIDER: S-EPMC4888457 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature