Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity.

ABSTRACT: Dietary lipids are transported from the intestine through contractile lymphatics. Chronic lipid loads can adversely affect lymphatic function. However, the acute lymphatic pump response in the mesentery to a postprandial lipid meal has gone unexplored. In this study, we used the rat mesenteric collecting vessel as an in vivo model to quantify the effect of lipoproteins on vessel function. Lipid load was continuously monitored by using the intensity of a fluorescent fatty-acid analog, which we infused along with a fat emulsion through a duodenal cannula. The vessel contractility was simultaneously quantified. We demonstrated for the first time that collecting lymphatic vessels respond to an acute lipid load by reducing pump function. High lipid levels decreased contraction frequency and amp

SUBMITTER: Kassis T 

PROVIDER: S-EPMC4888550 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature