Therapeutic effect of dexamethasone implant in retinal vein occlusions resistant to anti-VEGF therapy.

ABSTRACT:

Purpose

To test the efficacy of the intravitreal dexamethasone (DEX) implant in patients with retinal vein occlusions (RVOs) who have failed multiple anti-vascular endothelial growth factor (anti-VEGF) treatments.

Methods

A randomized exploratory study of ten patients with branch RVO or central RVO who received at least two previous anti-VEGF treatments and had persistent or unresponsive cystoid macular edema. Treatment with the DEX implant was either every 4 months or pro re nata (PRN) depending on their group assignment for 1 year. Multifocal electroretinography and microperimetry were the primary end points, with high-resolution optical coherence tomography and best-corrected visual acuity as the secondary end points.

Results

All patients in both the every 4 month

SUBMITTER: Wallsh J 

PROVIDER: S-EPMC4888726 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature