Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.

ABSTRACT:

Objectives

Fibromyalgia (FM) is a common pain disorder characterized by nociceptive dysregulation. The basic biology of FM is poorly understood. Herein we have used agnostic gene expression as a potential probe for informing its underlying biology and the development of a proof-of-concept diagnostic gene expression signature.

Methods

We analyzed RNA expression in 70 FM patients and 70 healthy controls. The isolated RNA was amplified and hybridized to Affymetrix® Human Gene 1.1 ST Peg arrays. The data was analyzed using Partek Genomics Suite version 6.6.

Results

Fibromyalgia patients exhibited a differential expression of 421 genes (p<0.001), several relevant to pathways for pain processing, such as glutamine/glutamate signaling and axonal development. There was also a

SUBMITTER: Jones KD 

PROVIDER: S-EPMC4888802 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature