Antidepressant use and new-onset diabetes: a systematic review and meta-analysis.

ABSTRACT: Antidepressant use has been linked to new-onset diabetes. However, the existing literature on this relationship has yielded inconsistent findings. The primary objective of this study was to systematically synthesize the literature on the relationship between antidepressant use and new-onset diabetes using meta-analysis. A systematic literature search was conducted to identify relevant studies in seven electronic databases. Two independent reviewers identified the final list of studies to be included in the meta-analysis using a priori selection criteria. Results for the primary outcome of interest, that is, odds and hazards of developing new-onset diabetes, were pooled using a random-effects model. Egger's regression test and the Trim and Fill method were utilized to detect the presence of

SUBMITTER: Bhattacharjee S 

PROVIDER: S-EPMC4888867 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature