Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer.

ABSTRACT:

Background

Fibrinogen plays a key role in hemostasis and is the first coagulation factor to reach critical levels in bleeding patients. Current European guidelines on the management of traumatic or perioperative bleeding recommend fibrinogen supplementation at specific threshold levels. Whole blood viscoelastic tests provide fast evaluation of fibrin deficits. Fast measurement of plasma fibrinogen concentration is not yet available. We investigated a method to rapidly determine whole blood fibrinogen concentration using standard Clauss assays and a steel ball coagulometer and provide an estimate of the "plasma-equivalent" fibrinogen concentration within minutes by adjustment of the measured whole blood fibrinogen concentration with a quickly measureable hemoglobin-derived hematocri

SUBMITTER: Schlimp CJ 

PROVIDER: S-EPMC4888927 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature