Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand.

ABSTRACT:

Background

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development.

Methodology/principal findings

This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-cell antigen preparation), in homologous and heterologous serum-isolate pairs from the same endemic region in NE Thailand. The indirect immunofluorescence assay was used to titrate Orientia tsutsugamushi isolates and human sera, and a mathematic

SUBMITTER: James SL 

PROVIDER: S-EPMC4889052 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature