Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.

ABSTRACT: Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.

SUBMITTER: Skvortsova YV 

PROVIDER: S-EPMC4889060 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature