Impact of Insertion Sequences and Recombination on the Population Structure of Staphylococcus haemolyticus.

ABSTRACT: Staphylococcus haemolyticus is one of the most common pathogens associated with medical-device related infections, but its molecular epidemiology is poorly explored. In the current study, we aimed to better understand the genetic mechanisms contributing to S. haemolyticus diversity in the hospital environment and their impact on the population structure and clinical relevant phenotypic traits. The analysis of a representative S. haemolyticus collection by multilocus sequence typing (MLST) has identified a single highly prevalent and diverse genetic lineage of nosocomial S. haemolyticus clonal complex (CC) 29 accounting for 91% of the collection of isolates disseminated worldwide. The examination of the sequence changes at MLST loci during clonal diversification showed that recombination ha

SUBMITTER: Bouchami O 

PROVIDER: S-EPMC4889114 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature