GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas.

ABSTRACT:

Objective

Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients.

Methods

We evaluated GATA3 expression in 76 STS cases using immunohistochemical analysis, and statistically compared clinicopathological characteristics between GATA3-positive and GATA3-negative cases.

Result

GATA3-positive expression was significantly associated with a higher mitotic count (P < 0.0001). Disease-free survival (DFS) of GATA3-positive cases was significantly shorter than that of cases without GATA3 expression (P = 0.0104). Overall survival (OS) of GATA3-positive cases was significantly shorter th

SUBMITTER: Haraguchi T 

PROVIDER: S-EPMC4889143 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature