Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.

ABSTRACT: Integrating stress responses across tissues is essential for the survival of multicellular organisms. The metazoan nervous system can sense protein-misfolding stress arising in different subcellular compartments and initiate cytoprotective transcriptional responses in the periphery. Several subcellular compartments possess a homotypic signal whereby the respective compartment relies on a single signaling mechanism to convey information within the affected cell to the same stress-responsive pathway in peripheral tissues. In contrast, we find that the heat shock transcription factor, HSF-1, specifies its mode of transcellular protection via two distinct signaling pathways. Upon thermal stress, neural HSF-1 primes peripheral tissues through the thermosensory neural circuit to mount a heat sho

SUBMITTER: Douglas PM 

PROVIDER: S-EPMC4889220 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature