Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.

ABSTRACT: The development and progression of invasive breast cancer is characterized by alterations to the genome and epigenome. However, the relationship between breast tumor characteristics, disease subtypes, and patient outcomes with the cumulative burden of these molecular alterations are not well characterized. We determined the average departure of tumor DNA methylation from adjacent normal breast DNA methylation using Illumina 450K methylation data from 700 invasive breast tumors and 90 adjacent normal breast tissues in The Cancer Genome Atlas. From this we generated a novel summary measure of altered DNA methylation, the DNA methylation dysregulation index (MDI), and examined the relation of MDI with tumor characteristics and summary measures that quantify cumulative burden of genetic mutati

SUBMITTER: O'Sullivan DE 

PROVIDER: S-EPMC4889287 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature