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Option A improved HIV-free infant survival and mother to child HIV transmission at 9-18 months in Zimbabwe.

ABSTRACT: We evaluated the impact of Option A on HIV-free infant survival and mother-to-child transmission (MTCT) in Zimbabwe.Serial cross-sectional community-based serosurveys.We analyzed serosurvey data collected in 2012 and 2014 among mother-infant pairs from catchment areas of 132 health facilities from five of 10 provinces in Zimbabwe. Eligible infants (alive or deceased) were born 9-18 months before each survey to mothers at least 16 years old. We randomly selected mother-infant pairs and conducted questionnaires, verbal autopsies, and collected blood samples. We estimated the HIV-free infant survival and MTCT rate within each catchment area and compared the 2012 and 2014 estimates using a paired t test and number of HIV infections averted because of the intervention.We analyzed 7249 mother-infant pairs with viable maternal specimens collected in 2012 and 8551 in 2014. The mean difference in the catchment area level MTCT between 2014 and 2012 was -5.2 percentage points (95% confidence interval?=?-8.1, -2.3, P?

SUBMITTER: Buzdugan R 

PROVIDER: S-EPMC4889511 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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<h4>Objective</h4>We evaluated the impact of Option A on HIV-free infant survival and mother-to-child transmission (MTCT) in Zimbabwe.<h4>Design</h4>Serial cross-sectional community-based serosurveys.<h4>Methods</h4>We analyzed serosurvey data collected in 2012 and 2014 among mother-infant pairs from catchment areas of 132 health facilities from five of 10 provinces in Zimbabwe. Eligible infants (alive or deceased) were born 9-18 months before each survey to mothers at least 16 years old. We ran  ...[more]