Reproductive Risk Factors and Coronary Heart Disease in the Women's Health Initiative Observational Study.

ABSTRACT:

Background

Reproductive factors provide an early window into a woman's coronary heart disease (CHD) risk; however, their contribution to CHD risk stratification is uncertain.

Methods and results

In the Women's Health Initiative Observational Study, we constructed Cox proportional hazards models for CHD including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, age at first birth, stillbirths, miscarriages, infertility ≥1 year, infertility cause, and breastfeeding. We next added each candidate reproductive factor to an established CHD risk factor model. A final model was then constructed with significant reproductive factors added to established CHD risk factors. Improvement in C statistic, net reclassification index (or net reclassificat

SUBMITTER: Parikh NI 

PROVIDER: S-EPMC4889516 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature