Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?

ABSTRACT:

Objective

Nelfinavir exhibits potent anticancer properties against a range of tumours. However, in 2006/2007, nelfinavir supplies were accidently contaminated with a carcinogen. This analysis investigated the association between nelfinavir use and cancer risk in HIV-positive persons.

Design

Observational cohort study.

Methods

D:A:D study data was analysed using Poisson regression models to examine associations between cancer incidence and cumulative nelfinavir exposure, current nelfinavir exposure, and exposure to nelfinavir between 1 July 2006-30 June 2007.

Results

A total of 42 006 individuals (50% white, 73% male) contributed 303 005 person-years of follow-up between 1 January 2004 and 1 February 2014. At study enrolment, median age was 40 [interquartile ran

SUBMITTER: Boettiger DC 

PROVIDER: S-EPMC4889546 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature