A Topological Model of the Hippocampal Cell Assembly Network.

ABSTRACT: It is widely accepted that the hippocampal place cells' spiking activity produces a cognitive map of space. However, many details of this representation's physiological mechanism remain unknown. For example, it is believed that the place cells exhibiting frequent coactivity form functionally interconnected groups-place cell assemblies-that drive readout neurons in the downstream networks. However, the sheer number of coactive combinations is extremely large, which implies that only a small fraction of them actually gives rise to cell assemblies. The physiological processes responsible for selecting the winning combinations are highly complex and are usually modeled via detailed synaptic and structural plasticity mechanisms. Here we propose an alternative approach that allows modeling the c

SUBMITTER: Babichev A 

PROVIDER: S-EPMC4889593 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature