NetDecoder: a network biology platform that decodes context-specific biological networks and gene activities.

ABSTRACT: The sequential chain of interactions altering the binary state of a biomolecule represents the 'information flow' within a cellular network that determines phenotypic properties. Given the lack of computational tools to dissect context-dependent networks and gene activities, we developed NetDecoder, a network biology platform that models context-dependent information flows using pairwise phenotypic comparative analyses of protein-protein interactions. Using breast cancer, dyslipidemia and Alzheimer's disease as case studies, we demonstrate NetDecoder dissects subnetworks to identify key players significantly impacting cell behaviour specific to a given disease context. We further show genes residing in disease-specific subnetworks are enriched in disease-related signalling pathways and inf

SUBMITTER: da Rocha EL 

PROVIDER: S-EPMC4889937 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature