Ontology highlight
ABSTRACT:
SUBMITTER: Ip JY
PROVIDER: S-EPMC4890022 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20160602
The long noncoding RNA Gomafu/MIAT/Rncr2 is thought to function in retinal cell specification, stem cell differentiation and the control of alternative splicing. To further investigate physiological functions of Gomafu, we created mouse knockout (KO) model that completely lacks the Gomafu gene. The KO mice did not exhibit any developmental deficits. However, behavioral tests revealed that the KO mice are hyperactive. This hyperactive behavior was enhanced when the KO mice were treated with the p ...[more]