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Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.


ABSTRACT: We conducted high-dimensional propensity score-adjusted cohort studies to examine whether thiazolidinedione use with a statin or fibrate was associated with an increased risk of severe hypoglycemia. We found that concomitant therapy with a thiazolidinedione+fibrate was associated with a generally delayed increased risk of severe hypoglycemia.

SUBMITTER: Leonard CE 

PROVIDER: S-EPMC4890073 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.

Leonard Charles E CE   Han Xu X   Bilker Warren B WB   Flory James H JH   Brensinger Colleen M CM   Flockhart David A DA   Gagne Joshua J JJ   Cardillo Serena S   Hennessy Sean S  

Diabetes research and clinical practice 20160314


We conducted high-dimensional propensity score-adjusted cohort studies to examine whether thiazolidinedione use with a statin or fibrate was associated with an increased risk of severe hypoglycemia. We found that concomitant therapy with a thiazolidinedione+fibrate was associated with a generally delayed increased risk of severe hypoglycemia. ...[more]

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