Decreased fecundity and sperm DNA methylation patterns.

ABSTRACT:

Objective

To evaluate the relationship between epigenetic patterns in sperm and fecundity.

Design

Prospective study.

Setting

Academic andrology and in vitro fertilization laboratory.

Patient(s)

Twenty-seven semen samples from couples who conceived within 2 months of attempting a pregnancy and 29 semen samples from couples unable to achieve a pregnancy within 12 months.

Intervention(s)

None.

Main outcome measure(s)

Genomewide assessment of differential sperm DNA methylation and standard semen analysis.

Result(s)

We analyzed DNA methylation alterations associated with fecundity in 124 semen samples, and identified regions of interest in 27 semen samples from couples who conceived within 2 months of attempting a pregnancy and a total of 29 sem

SUBMITTER: Jenkins TG 

PROVIDER: S-EPMC4890464 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature