Analysis of coevolution in nonstructural proteins of chikungunya virus.

ABSTRACT:

Background

RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-species. The stability of strains within the quasi-species lies on mutations that are positively selected which in turn depend on whether these mutations are beneficial in either or both hosts. Coevolution of amino acids (aa) is one phenomenon that leads to establishment of favorable traits in viruses and leading to their fitness.

Results

Fourteen CHIKV clinical samples collected over three years were subjected to RT-PCR, the four non-structural genes amplified and

SUBMITTER: Jain J 

PROVIDER: S-EPMC4890524 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature