Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells.
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ABSTRACT:
SUBMITTER: Angrisano T
PROVIDER: S-EPMC4890762 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells.
Angrisano Tiziana T Pero Raffaela R Brancaccio Mariarita M Coretti Lorena L Florio Ermanno E Pezone Antonio A Calabrò Viola V Falco Geppino G Keller Simona S Lembo Francesca F Avvedimento Vittorio Enrico VE Chiariotti Lorenzo L
PloS one 20160602 6
Bacterial lipopolysaccharide (LPS) induces release of inflammatory mediators both in immune and epithelial cells. We investigated whether changes of epigenetic marks, including selected histone modification and DNA methylation, may drive or accompany the activation of COX-2 gene in HT-29 human intestinal epithelial cells upon exposure to LPS. Here we describe cyclical histone acetylation (H3), methylation (H3K4, H3K9, H3K27) and DNA methylation changes occurring at COX-2 gene promoter overtime a ...[more]
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