Evolution-Based Functional Decomposition of Proteins.

ABSTRACT: The essential biological properties of proteins-folding, biochemical activities, and the capacity to adapt-arise from the global pattern of interactions between amino acid residues. The statistical coupling analysis (SCA) is an approach to defining this pattern that involves the study of amino acid coevolution in an ensemble of sequences comprising a protein family. This approach indicates a functional architecture within proteins in which the basic units are coupled networks of amino acids termed sectors. This evolution-based decomposition has potential for new understandings of the structural basis for protein function. To facilitate its usage, we present here the principles and practice of the SCA and introduce new methods for sector analysis in a python-based software package (pySCA).

SUBMITTER: Rivoire O 

PROVIDER: S-EPMC4890866 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature