Seizure-like discharges induced by 4-aminopyridine in the olfactory system of the in vitro isolated guinea pig brain.

ABSTRACT:

Purpose

The study of the interactions leading to network- or region-specific propagation of seizures is crucial to understand ictogenesis. We have recently found that systemic (arterial) application of the potassium channel blocker, 4-aminopyridine (4AP), induces different and independent seizure activities in olfactory and in limbic structures. Here, we have characterized the network and cellular features that support 4AP-induced seizure-like events in the olfactory cortex.

Methods

Simultaneous extracellular recordings were performed from the piriform cortex, the entorhinal cortex, the olfactory tubercle, and the amygdala of the in vitro isolated guinea pig brain preparation. Intracellular, sharp electrode recordings were obtained from neurons of different layers of the reg

SUBMITTER: Uva L 

PROVIDER: S-EPMC4891192 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature