Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage.

ABSTRACT:

Objective

We aimed to describe the temporal variation in circulating lipid levels among patients with intracerebral hemorrhage (ICH) and investigate their association with ICH risk.

Methods

This was a single-center, retrospective, longitudinal, case-control analysis using cases drawn from an ongoing cohort study of primary ICH and controls drawn from a hospital-based clinical data registry. Piecewise linear mixed-effect random coefficient models were used to determine the significance of changes in serum lipid trends on ICH risk.

Results

Two hundred twelve ICH cases and 301 control individuals were analyzed. Overall trends in serum total cholesterol (TC) and low-density lipoprotein (LDL) levels differed between ICH cases and non-ICH controls (p = 0.00001 and p = 0.009

SUBMITTER: Phuah CL 

PROVIDER: S-EPMC4891207 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature