Multimorbidity and neuroimaging biomarkers among cognitively normal persons.

ABSTRACT:

Objective

To assess the cross-sectional association between multimorbidity and imaging biomarkers of brain pathology in the population-based Mayo Clinic Study of Aging (MCSA).

Methods

The study consisted of 1,449 MCSA participants who were cognitively normal at the time of MRI. A subset of the participants also had (11)C-Pittsburgh compound B (n = 689) and (18)fluorodeoxyglucose (n = 688) PET scans available. Information on multimorbidity (defined as ≥2 chronic conditions) in the 5 years prior to the first imaging study was captured from the medical record using ICD-9 codes for chronic conditions and the Rochester Epidemiology Project medical records linkage system. The cross-sectional association of multimorbidity and imaging biomarkers was examined using logistic and linea

SUBMITTER: Vassilaki M 

PROVIDER: S-EPMC4891208 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature