Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial.

ABSTRACT:

Objective

To determine whether vitamin E would slow the progression of cognitive deterioration and dementia in aging persons with Down syndrome (DS).

Methods

A randomized, double-blind controlled clinical trial was conducted at 21 clinical sites, and researchers trained in research procedures recruited adults with DS older than 50 years to participate. Participants were randomly assigned to receive 1,000 IU of vitamin E orally twice daily for 3 years or identical placebo. The primary outcome was change on the Brief Praxis Test (BPT). Secondary outcomes included incident dementia and measures of clinical global change, cognition, function, and behavior.

Results

A total of 337 individuals were randomized, 168 to vitamin E and 169 to placebo. Both groups demonstrated det

SUBMITTER: Sano M 

PROVIDER: S-EPMC4891209 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature