Randomised clinical trial: mixed soluble/insoluble fibre vs. psyllium for chronic constipation.

ABSTRACT:

Background

Fibre supplements are useful, but whether a plum-derived mixed fibre that contains both soluble and insoluble fibre improves constipation is unknown.

Aim

To investigate the efficacy and tolerability of mixed soluble/insoluble fibre vs. psyllium in a randomized double-blind controlled trial.

Methods

Constipated patients (Rome III) received mixed fibre or psyllium, 5 g b.d., for 4 weeks. Daily symptoms and stool habit were assessed using stool diary. Subjects with ≥1 complete spontaneous bowel movement/week above baseline for ≥2/4 weeks were considered responders. Secondary outcome measures included stool consistency, bowel satisfaction, straining, gas, bloating, taste, dissolvability and quality of life (QoL).

Results

Seventy-two subjects (mixed fibre

SUBMITTER: Erdogan A 

PROVIDER: S-EPMC4891216 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature