No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort.

ABSTRACT:

Background

Mitochondria are involved in many processes that are central to the life and death of a cell. Oxidative phosphorylation (OXPHOS), in particular, is known to be altered in carcinogenesis, leading to an increase in the production of reactive oxidative species and glycolysis, one of the hallmarks of cancer cells. Because of this, genetic variation in the mitochondrial genome, which encodes for part of the OXPHOS pathway, has been suggested to play a role in many cancers, including prostate cancer.

Methods

We comprehensively examined the role of the mitochondrial genome and prostate cancer risk in 4,086 prostate cancer cases and 3,698 controls from the Multiethnic Cohort (MEC), testing 350 mitochondrial SNPs (mtSNPs) in five racial/ethnic populations-Africans, Asian A

SUBMITTER: Giorgi EE 

PROVIDER: S-EPMC4891274 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature