A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus.

ABSTRACT:

Background

Better methods are needed to predict risk of progression for Barrett's esophagus. We aimed to determine whether a tissue systems pathology approach could predict progression in patients with nondysplastic Barrett's esophagus, indefinite for dysplasia, or low-grade dysplasia.

Methods

We performed a nested case-control study to develop and validate a test that predicts progression of Barrett's esophagus to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC), based upon quantification of epithelial and stromal variables in baseline biopsies. Data were collected from Barrett's esophagus patients at four institutions. Patients who progressed to HGD or EAC in ≥1 year (n = 79) were matched with patients who did not progress (n = 287). Biopsies were assigned ran

SUBMITTER: Critchley-Thorne RJ 

PROVIDER: S-EPMC4891291 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature