Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.

ABSTRACT:

Background

Lung cancer is a major health burden causing 160,000 and 1.6 million deaths annually in the United States and worldwide, respectively.

Methods

While seeking to identify stable and reproducible biomarkers in noninvasively collected biofluids, we assessed whether previously identified metabolite urinary lung cancer biomarkers, creatine riboside (CR), N-acetylneuraminic acid (NANA), cortisol sulfate, and indeterminate metabolite 561+, were elevated in the urines of subjects prior to lung cancer diagnosis in a well-characterized prospective Southern Community Cohort Study (SCCS). Urine was examined from 178 patients and 351 nondiseased controls, confirming that one of four metabolites was associated with lung cancer risk in the overall case-control set, whereas two me

SUBMITTER: Haznadar M 

PROVIDER: S-EPMC4891298 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature