Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in mice.

ABSTRACT: Murine zymosan-induced peritonitis is a widely used model for studying the molecular and cellular events responsible for the initiation, persistence and/or resolution of inflammation. Among these events, it is becoming increasingly evident that changes in glycosylation of proteins, especially in the plasma and at the site of inflammation, play an important role in the inflammatory response. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS)-based glycosylation profiling, we investigated the qualitative and quantitative effect of zymosan-induced peritonitis on N-glycosylation in mouse plasma and peritoneal fluid. Our results show that both N-glycomes exhibit highly similar glycosylation patterns, consisting mainly of diantennary and triantennar

SUBMITTER: Rombouts Y 

PROVIDER: S-EPMC4891370 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature