Improving the clinical potential of ultra-high field fMRI using a model-free analysis method based on response consistency.

ABSTRACT:

Objective

To develop an analysis method that is sensitive to non-model-conform responses often encountered in ultra-high field presurgical planning fMRI. Using the consistency of time courses over a number of experiment repetitions, it should exclude low quality runs and generate activation maps that reflect the reliability of responses.

Materials and methods

7 T fMRI data were acquired from six healthy volunteers: three performing purely motor tasks and three a visuomotor task. These were analysed with the proposed approach (UNBIASED) and the GLM.

Results

UNBIASED results were generally less affected by false positive results than the GLM. Runs that were identified as being of low quality were confirmed to contain little or no activation. In two cases, regions were i

SUBMITTER: Cardoso PL 

PROVIDER: S-EPMC4891377 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature