Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers.

ABSTRACT: Psychoactive pharmaceuticals have been found as teratogens at clinical dosage during pregnancy. These pharmaceuticals have also been detected in minute (ppb) concentrations in drinking water in the US, and are environmental contaminants that may be complicit in triggering neurological disorders in genetically susceptible individuals. Previous studies have determined that psychoactive pharmaceuticals (fluoxetine, venlafaxine and carbamazepine) at environmentally relevant concentrations enriched sets of genes regulating development and function of the nervous system in fathead minnows. Altered gene sets were also associated with potential neurological disorders, including autism spectrum disorders (ASD). Subsequent in vitro studies indicated that psychoactive pharmaceuticals altered ASD-asso

SUBMITTER: Kaushik G 

PROVIDER: S-EPMC4891464 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature