Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study.

ABSTRACT:

Background

A protective effect of tricyclic antidepressants (TCAs) against gliomas has been suggested by a small number of studies. We investigated this putative association in a nationwide setting.

Methods

Using a case-control design, we identified all patients with histologically verified glioma (cases) in Denmark between 2000 and 2012 and matched these 1 : 20 to population controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) for glioma associated with long-term (⩾3 years) use of TCAs. Similar analyses were performed for selective serotonin reuptake inhibitors (SSRIs).

Results

We identified 3767 glioma cases and 75 340 population controls. Long-term use of TCAs was inversely associated with risk of glioma (OR 0.72, 95% CI: 0.41-1

SUBMITTER: Pottegard A 

PROVIDER: S-EPMC4891498 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature