Meta-analysis of breast cancer mortality benefit and overdiagnosis adjusted for adherence: improving information on the effects of attending screening mammography.

ABSTRACT:

Background

Women require information about the impact of regularly attending screening mammography on breast cancer mortality and overdiagnosis to make informed decisions. To provide this information we aimed to meta-analyse randomised controlled trials adjusted for adherence to the trial protocol.

Methods

Nine screening mammography trials used in the Independent UK Breast Screening Report were selected. Extending an existing approach to adjust intention-to-treat (ITT) estimates for less than 100% adherence rates, we conducted a random-effects meta-analysis. This produced a combined deattenuated prevented fraction and a combined deattenuated percentage risk of overdiagnosis.

Results

In women aged 39-75 years invited to screen, the prevented fraction of breast cancer m

SUBMITTER: Jacklyn G 

PROVIDER: S-EPMC4891513 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature