Chromatin changes predict recurrence after radical prostatectomy.

ABSTRACT:

Background

Pathological evaluations give the best prognostic markers for prostate cancer patients after radical prostatectomy, but the observer variance is substantial. These risk assessments should be supported and supplemented by objective methods for identifying patients at increased risk of recurrence. Markers of epigenetic aberrations have shown promising results in several cancer types and can be assessed by automatic analysis of chromatin organisation in tumour cell nuclei.

Methods

A consecutive series of 317 prostate cancer patients treated with radical prostatectomy at a national hospital between 1987 and 2005 were followed for a median of 10 years (interquartile range, 7-14). On average three tumour block samples from each patient were included to account for tumou

SUBMITTER: Hveem TS 

PROVIDER: S-EPMC4891515 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature