Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population.

ABSTRACT:

Background

Lifestyle factors such as diet and physical activity have been shown to modify the association between fat mass and obesity-associated (FTO) gene variants and metabolic traits in several populations; however, there are no gene-lifestyle interaction studies, to date, among Asian Indians living in India. In this study, we examined whether dietary factors and physical activity modified the association between two FTO single nucleotide polymorphisms (rs8050136 and rs11076023) (SNPs) and obesity traits and type 2 diabetes (T2D).

Methods

The study included 734 unrelated T2D and 884 normal glucose-tolerant (NGT) participants randomly selected from the urban component of the Chennai Urban Rural Epidemiology Study (CURES). Dietary intakes were assessed using a validated in

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC4891824 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature