Statistical inference of a convergent antibody repertoire response to influenza vaccine.

ABSTRACT:

Background

Vaccines dramatically affect an individual's adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus. This process may alter the composition of B cell lineages within an individual, which are known collectively as the antibody repertoire (AbR). Antibodies are also highly expressed in whole blood, potentially enabling RNA sequencing (RNA-seq) technologies to query this diversity. Less is known about the diversity of AbR responses across individuals to a given vaccine and if individuals tend to yield a similar response to the same antigenic stimulus.

Methods

Here we implement a

SUBMITTER: Strauli NB 

PROVIDER: S-EPMC4891843 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature