Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea.

ABSTRACT:

Background

Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-producing actinomycete Saccharopolyspora erythraea. Further yield increase is of great importance but requires a better understanding of the underlying physiological processes.

Results

To reveal the mechanisms related to erythromycin yield increase, we have undertaken an integrated study of the genomic, transcriptomic, and proteomic differences between the wild type strain NRRL2338 (WT) and the industrial high-producing strain ABE1441 (HP) of S. erythraea at multiple time points of a

SUBMITTER: Karnicar K 

PROVIDER: S-EPMC4891893 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature