Alzheimer's disease: are blood and brain markers related? A systematic review.

ABSTRACT:

Objective

Peripheral protein biomarkers of Alzheimer's disease (AD) may help identify novel treatment avenues by allowing early diagnosis, recruitment to clinical trials, and treatment initiation. The purpose of this review was to determine which proteins have been found to be differentially expressed in the AD brain and whether these proteins are also found within the blood of AD patients.

Methods

A two-stage approach was conducted. The first stage involved conducting a systematic search to identify discovery-based brain proteomic studies of AD. The second stage involved comparing whether proteins found to be differentially expressed in AD brain were also differentially expressed in the blood.

Results

Across 11 discovery based brain proteomic studies 371 proteins wer

SUBMITTER: Khan AT 

PROVIDER: S-EPMC4891999 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature