Population distribution of lifetime risk of ovarian cancer in the United States.

ABSTRACT:

Background

In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average.

Methods

We have characterized the distribution of lifetime risk in the general population. Published data on the relative risks and their variances for five well-accepted risk and protective factors for ovarian cancer, oral contraceptive use, parity, tubal ligation, endometriosis, and first-degree family history of ovarian cancer in conjunction with a genetic risk score using genome-wide significant common, low penetrance variants were used. The joint distribution of these factors (i.e., risk/protective factor profiles) was derived using control data from four U.S. population-based studies, providing a broad representation of women

SUBMITTER: Pearce CL 

PROVIDER: S-EPMC4892114 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature