Effects of antibiotic resistance alleles on bacterial evolutionary responses to viral parasites.

ABSTRACT: Antibiotic resistance has wide-ranging effects on bacterial phenotypes and evolution. However, the influence of antibiotic resistance on bacterial responses to parasitic viruses remains unclear, despite the ubiquity of such viruses in nature and current interest in therapeutic applications. We experimentally investigated this by exposing various Escherichia coli genotypes, including eight antibiotic-resistant genotypes and a mutator, to different viruses (lytic bacteriophages). Across 960 populations, we measured changes in population density and sensitivity to viruses, and tested whether variation among bacterial genotypes was explained by their relative growth in the absence of parasites, or mutation rate towards phage resistance measured by fluctuation tests for each phage. We found tha

SUBMITTER: Arias-Sanchez FI 

PROVIDER: S-EPMC4892242 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature