MRI Based Preterm White Matter Injury Classification: The Importance of Sequential Imaging in Determining Severity of Injury.

ABSTRACT:

Background

The evolution of non-hemorrhagic white matter injury (WMI) based on sequential magnetic resonance imaging (MRI) has not been well studied. Our aim was to describe sequential MRI findings in preterm infants with non-hemorrhagic WMI and to develop an MRI classification system for preterm WMI based on these findings.

Methods

Eighty-two preterm infants (gestation ≤35 weeks) were retrospectively included. WMI was diagnosed and classified based on sequential cranial ultrasound (cUS) and confirmed on MRI.

Results

138 MRIs were obtained at three time-points: early (<2 weeks; n = 32), mid (2-6 weeks; n = 30) and term equivalent age (TEA; n = 76). 63 infants (77%) had 2 MRIs during the neonatal period. WMI was non-cystic in 35 and cystic in 47 infants. In infants wit

SUBMITTER: Martinez-Biarge M 

PROVIDER: S-EPMC4892507 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature